Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Introduction: Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to be very efficacious for the management of various diseases including giardiasis, toilet infections, hypertension, diabetes, ulcer, impotence, low libido, sperm count amongst others. Medicinal plants reportedly produce an array adverse reactions capable inducing harmful conditions, death. Aim: This study evaluated subchronic toxicity concern HF on testicular function gonadal histoarchitecture Wistar rats. Methods: Thirty rats both sexes were randomly divided into six groups (5/group) orally administered 60 days. The control received 5 mL/kg distilled water; treatment 476.24 158.75 mg/kg body weight each male female Using standard procedures, semen analysis was done all Animals anaesthetised sacrificed 62nd day; gonads eviscerated, weighed fixed 10% buffered formalin histopathological examinations. Results: Significant (p